High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

Department of Defense · DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) · Solicitation · DARPA-PA-27-01

posted 8 October 2026 · closes 5 November 2026 · NAICS 541714 · PSC AC12

Summary

DARPA is soliciting proposals to develop an in‑silico capability for high‑throughput mapping of protein‑protein interactions, called the Binding Landscape Emulators (HUBBLE). The effort aims to identify novel diagnostic and therapeutic targets, including those relevant to traumatic brain injury.

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