Protein ENGineering (PENG)

Department of Defense · DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) · Solicitation · DARPA-PS-26-129

posted 7 August 2026 · closes 19 October 2026 · NAICS 541714 · PSC AC12 · 2 postings

Summary

DARPA is soliciting proposals to develop a multifunctional, target‑agnostic platform for precise, programmable editing of endogenous proteins under the Protein ENGineering (PENG) program. The effort aims to create a universal, software‑defined proteome engineering capability that integrates modular targeting, generalizable effector chemistries, and multiplexed control systems, with validation in high‑fidelity cellular models such as organoids.

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